Detection of proteomic biomarkers of early diagnosis of preeclampsia and IUGR

Doctoral Dissertation uoadl:1305698 126 Read counter

Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
Μπαγιώκος Βασίλειος
Dissertation committee:
Α.Καλπίνη Μαύρου, Α. Αντσακλής, Ν. Παπαντωνίου
Original Title:
Ανίχνευση πρωτεωμικών δεικτών πρώιμης διάγνωσης προεκλαμψίας και IUGR
Translated title:
Detection of proteomic biomarkers of early diagnosis of preeclampsia and IUGR
Preeclampsia (PE) is a multifactorial and multisystem complication of pregnancy
of unknown origin, occurring in 3-5% of pregnant women which affects both the
mother and the foetus. Worldwide, it is the second leading cause of maternal
death in pregnancy (18 %) and is responsible for about 7-9 % of neonatal
morbidity and mortality.
Presently, the diagnosis of PE is based on the presence of at least two of the
classic symptoms, which are hypertension, proteinuria and oedema. Before the
clinical onset of PE a large number of biochemical changes have already
occurred expressing the pathogenetic events associated with the occurrence of
this complication. Although a large number of combinations of ultrasound and
biochemical markers leading to increased sensitivity and specificity for early
detection of PE have been studied there is as yet no, strong, high sensitivity
marker for PE screening.
Proteomic analysis is currently increasingly used to investigate the
pathogenetic mechanism responsible for various diseases. Proteomics allows for
the qualitative and quantitative comparison of the whole proteome of a
biological material, under different conditions, in order to investigate
various biological processes. It has the possibility to study massively and
simultaneously a huge number of proteins with regard to their structure,
post-translational changes in their interactions with other biological
molecules and changes in the expression level in pathological situations.
Preeclampsia, Intrauterine growth restriction, Proteomics, Early detection of preeclampsia, Biomarkers
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