Γενετικά χαρακτηριστικά κυπρίων ασθενών με σηπτικό σύνδρομο σε έδαφος χρόνιας νεφρικής ανεπάρκειας

Doctoral Dissertation uoadl:1305884 139 Read counter

Unit:
Τομέας Παθολογίας
Library of the School of Health Sciences
Deposit date:
2016-03-08
Year:
2015
Author:
Παναγίδου Αλεξία
Dissertation committee:
Ευάγγελος Ι. Γιαμαρέλλος Μπουρμπούλης, Αναπλ. Καθηγητής, Ελένη Γιαμαρέλλου ,Καθηγήτρια, Κυριακή Κανελλακοπούλου, Καθηγήτρια
Original Title:
Γενετικά χαρακτηριστικά κυπρίων ασθενών με σηπτικό σύνδρομο σε έδαφος χρόνιας νεφρικής ανεπάρκειας
Languages:
Greek
Summary:
BACKGROUND: Single nucleotide polymorphisms (SNPs) of interleukin (IL)-6 are
associated with the development of chronic renal disease(CRD). Their impact for
sepsis in the field of CRD was investigated.
METHODS: One control cohort of 115 patients with CRD without infection and
another case cohort of 198 patients with CRD and sepsis were enrolled.
Genotyping at the -174 (rs1800795) and -572 (rs1800796) was done by restriction
fragment length polymorphism. Circulating IL-6 was measured by an enzyme
immunoassay.
RESULTS: The GG genotype of rs1800796 was more frequent among cases (78.3%)
than controls (62.6%). No difference in the genotype frequencies of rs1800795
between cases and controls was found. Odds ratio for sepsis was 2.07 (95% CIs:
1.24-3.44, p=0.005) with the GG genotype of rs1800796 ,which was confirmed by
logistic regression analysis taking into consideration the presence of chronic
co morbidities. All-cause mortality until day 28 was similar between patients
with the GG genotype and the GC/CC genotypes of rs1800796, but death caused
from cardiovascular events not-related with infection was more frequent with
the GG genotype (25.8% vs 2.4%, p=0.031). Circulating IL-6 was greater among
patients of the GC/CC genotypes of rs1800796 and multiple organ dysfunction
(p=0.013).
CONCLUSIONS: The GG genotype of rs1800796 predisposes to sepsis in CRD and to
28-day mortality by sepsis-unrelated cardiovascular phenomena.
Keywords:
Septic syndrome, Chronic renal disease, PCR, Polymorphism, Electrophoresis
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
106
Number of pages:
112
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