Τομέας ΠαθολογίαςLibrary of the School of Health Sciences
Ευάγγελος Ι. Γιαμαρέλλος Μπουρμπούλης, Αναπλ. Καθηγητής, Ελένη Γιαμαρέλλου ,Καθηγήτρια, Κυριακή Κανελλακοπούλου, Καθηγήτρια
Γενετικά χαρακτηριστικά κυπρίων ασθενών με σηπτικό σύνδρομο σε έδαφος χρόνιας νεφρικής ανεπάρκειας
BACKGROUND: Single nucleotide polymorphisms (SNPs) of interleukin (IL)-6 are
associated with the development of chronic renal disease(CRD). Their impact for
sepsis in the field of CRD was investigated.
METHODS: One control cohort of 115 patients with CRD without infection and
another case cohort of 198 patients with CRD and sepsis were enrolled.
Genotyping at the -174 (rs1800795) and -572 (rs1800796) was done by restriction
fragment length polymorphism. Circulating IL-6 was measured by an enzyme
RESULTS: The GG genotype of rs1800796 was more frequent among cases (78.3%)
than controls (62.6%). No difference in the genotype frequencies of rs1800795
between cases and controls was found. Odds ratio for sepsis was 2.07 (95% CIs:
1.24-3.44, p=0.005) with the GG genotype of rs1800796 ,which was confirmed by
logistic regression analysis taking into consideration the presence of chronic
co morbidities. All-cause mortality until day 28 was similar between patients
with the GG genotype and the GC/CC genotypes of rs1800796, but death caused
from cardiovascular events not-related with infection was more frequent with
the GG genotype (25.8% vs 2.4%, p=0.031). Circulating IL-6 was greater among
patients of the GC/CC genotypes of rs1800796 and multiple organ dysfunction
CONCLUSIONS: The GG genotype of rs1800796 predisposes to sepsis in CRD and to
28-day mortality by sepsis-unrelated cardiovascular phenomena.
Septic syndrome, Chronic renal disease, PCR, Polymorphism, Electrophoresis
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