Estimation of global HIV-1 epidemic dispersal by means of phylogeography

Doctoral Dissertation uoadl:1306113 655 Read counter

Unit:
Τομέας Κοινωνικής Ιατρικής - Ψυχιατρικής και Νευρολογίας
Library of the School of Health Sciences
Deposit date:
2016-07-27
Year:
2016
Author:
Μαμάης Ιωάννης
Dissertation committee:
Δημήτριος Παρασκευής, Παναγιώτα Τουλούμη, Βάνα Σύψα
Original Title:
Εκτίμηση διασποράς της επιδημίας HIV-1 ανά την υφήλιο με μεθόδους μοριακής επιδημιολογίας
Languages:
Greek
Translated title:
Estimation of global HIV-1 epidemic dispersal by means of phylogeography
Summary:
Methods: With the above thesis there is an assessment of transmission events
between different populations globally with statistical phylogeography methods.
There had been collected a large number of HIV-1 sequences from Europe and
phylogenetic analysis evaluated the lineage of the virus populations from
different areas. Phylogeography methods based on the already estimated
genealogy, estimated the number of dispersal events between different
populations.
Results: Our study shows that the American continent has been influential in
driving the Western epidemic, not only at the initial random dispersal event
but also through constant subsequent mobility to the rest of the world.
Additionally, our study describes for the first time the global dispersal pat-
tern of CRF01_AE, highlighting the central role of Thailand as a major viral
exporter to the Western world. Finally, in a global context, HIV-1 subtype A
circulates into three geographically distinct clusters. Two of them have spread
mostly sexually (East and West/Central Africa) and the third (Eastern Europe)
through intravenous drug users (IDUs).

Conclusions: Our study highlights the use of phylogeographic analyses to
improve understanding of infectious diseases epidemics and factors potentially
associated with their spread.
Keywords:
HIV-1, Phylogeography, Phylogenetic analysis, Global dispersal, Molecular epidemiology
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
171
Number of pages:
165
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