Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences

2012-12-12

2012

Αραβίδου Ευτυχία

Καθηγητής Χρούσος Γεώργιος, Καθηγητής Μπότσης Δημήτριος, Επίκουρος Καθηγητής Αραβαντινός Λέων

Εμβρυϊκός προγραμματισμός (fetal programming) της ανάπτυξης του εγκεφάλου (brain development) μέσω επιγενετικών μεταβολών γονιδιακής έκφρασης σε επίμυες με υπολειπόμενη σωματική αύξηση (FGR- Fetal Growth Restriction)

Greek

Intrauterine growth restriction (IUGR) has been associated with increased pre-,
peri- and postnatal morbidity and mortality. Altered protein expression
profiles associated with IUGR may be informative on the pathological mechanisms
of this condition and might reveal potential markers for postnatal
complications. I.U.G.R. state was induced by maternal food restriction in a
moderate fashion (50%) during the last week of gestation. Two-dimensional
electrophoresis, mass spectrometry and Western blot analysis were employed in
brain tissue from I.U.G.R. newborn rats and control rats. We identified several
proteins which were differentially expressed between the two groups. Collapsin
response mediator proteins which are involved in neuronal growth, were found to
be reduced in I.U.G.R. group. Proteins related to energy-sensing pathways
(alpha-enolase) and redox status (peroxiredoxin-2, 14-3-3 protein epsilon and
gamma), molecular chaperones (calreticulin, heat shock 70, heat shock protein
HSP90-beta and T-complex protein) and enzymes (elongation factor 2 and pyruvate
kinase) were found to be differentially expressed between two groups. The
expression of alpha-fetoprotein, Pre-mRNA-processing factor 19 and fascin was
decreased in I.U.G.R. group. The altered expression of proteins reflects to
epigenetic programming during neonatal period of life and these specific
proteins may be involved in fetal programming of brain development in I.U.G.R.

Intrauterine growth restriction (IUGR), Brain development, Two dimensional electrophoresis , Proteomics , Fetal Programming

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https://pergamos.lib.uoa.gr/uoa/dl/object/1306139