Τομέας ΧειρουργικήςLibrary of the School of Health Sciences
Καθ. Πέτρος Καρακίτσος
Η κλινική σημασία της μοριακής ανάλυσης δεικτών που σχετίζονται με τη βιολογική συμπεριφορά και την πρόγνωση στον καρκίνο του παχέος εντέρου
The clinical significance of molecular analysis of markers related to the biological behavior and prognosis in colorectal cancer
A tumour “bud” is defined as a single tumour cell or tumour cell cluster up to
five cells at the invasive tumour front. Significant differences in survival
have been detected in colorectal cancer patients with low- compared to
Aim : to identify potential multi-marker phenotypes characterizing low- and
high-grade budding in mismatch repair (MMR) -proficient colorectal cancer.
Methods: Established and promising prognostic proteins , Bcl-2, EphB2, were
analyzed on 208 MMR-proficient colorectal cancers with complete
clinico-pathological data. Receiver operating characteristic curve (ROC)
analysis was used to determine appropriate cut-offs.
Results: EphB2 and Bcl-2 were found to be accurate markers for predicting
high grade budding (p<0.001). On multivariable analysis, loss of Bcl-2
(p<0.001) and EphB2 (p< 0.001) were very useful markers for predicting
Bcl 2- EphB2- tumours, were more frequently poorly differentiated, of
advanced pT stage, lymph node positive, presented vascular and lymphatic
invasion and had a negative impact on patient survival.
Conclusion: The multi-marker phenotype EphB2-/bcl2- is an independent predictor
of high-grade budding and implies an increased aggressive behaviour in
MMR-proficient colorectal cancer.
Bcl-2, Cancer, Colorectal, EphB2, Τumour budding
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