The clinical significance of molecular analysis of markers related to the biological behavior and prognosis in colorectal cancer

Doctoral Dissertation uoadl:1306606 79 Read counter

Unit:
Τομέας Χειρουργικής
Library of the School of Health Sciences
Deposit date:
2013-04-26
Year:
2013
Author:
Ράλλης Γεώργιος
Dissertation committee:
Καθ. Πέτρος Καρακίτσος
Original Title:
Η κλινική σημασία της μοριακής ανάλυσης δεικτών που σχετίζονται με τη βιολογική συμπεριφορά και την πρόγνωση στον καρκίνο του παχέος εντέρου
Languages:
Greek
Translated title:
The clinical significance of molecular analysis of markers related to the biological behavior and prognosis in colorectal cancer
Summary:
A tumour “bud” is defined as a single tumour cell or tumour cell cluster up to
five cells at the invasive tumour front. Significant differences in survival
have been detected in colorectal cancer patients with low- compared to
high-grade budding.
Aim : to identify potential multi-marker phenotypes characterizing low- and
high-grade budding in mismatch repair (MMR) -proficient colorectal cancer.
Methods: Established and promising prognostic proteins , Bcl-2, EphB2, were
analyzed on 208 MMR-proficient colorectal cancers with complete
clinico-pathological data. Receiver operating characteristic curve (ROC)
analysis was used to determine appropriate cut-offs.
Results: EphB2 and Bcl-2 were found to be accurate markers for predicting
high grade budding (p<0.001). On multivariable analysis, loss of Bcl-2
(p<0.001) and EphB2 (p< 0.001) were very useful markers for predicting
high-grade budding.
Bcl 2-  EphB2- tumours, were more frequently poorly differentiated, of
advanced pT stage, lymph node positive, presented vascular and lymphatic
invasion and had a negative impact on patient survival.
Conclusion: The multi-marker phenotype EphB2-/bcl2- is an independent predictor
of high-grade budding and implies an increased aggressive behaviour in
MMR-proficient colorectal cancer.
Keywords:
Bcl-2, Cancer, Colorectal, EphB2, Τumour budding
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
279
Number of pages:
124

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