Dissertation committee:
Καθηγητής Γενετικής κ. Καναβάκης Εμμανουήλ, Καθηγήτρια Γενετικής κ. Κίτσιου-Τζέλη Σοφία, Επίκουρη Καθηγήτρια Αναπτυξιακής Παιδιατρικής κ. Θωμαϊδου Λωρέττα
Summary:
ABSTRACT
Study purpose: The purpose of this study is the estimation of congenital
anomalies and psychomotor development of children born after PGD and evaluation
of their parents’ stress, in Greece.
Methods: The study population consisted of 53 PGD children, their 78 parents
and 52 parents of children conceived naturally. 51 PGD children received
clinical genetic evaluation, developmental examination (using Bayley and
Griffith’s Scales) at 6 months up to 8 years of age. Parental stress was
evaluated by Parental Stress Index-Short Form questionnaire (PSI-SF).
Results-Conclusions: We found increased frequency of prematurity (31,6%), of
multiple pregnancies (28,2%), of caesarian sections (87%) and of low birth
weight (29,4%). 15,7% of PGD children had at least one major anomaly.
Correlation of male gender with major anomalies was statistically significant
(P=0,05). The majority of PGD children had normal developmental quotients while
severe retardation was found in 3% regarding General Developmental Quotient,
5,9% regarding Mental Quotient and 6,5% regarding Motor Quotient. Most of the
PGD parents (71,1%) had normal parental stress levels and they also expressed
high stress less often (2,6% versus 17,3% in the control group).
This study, the first in Greece and third worldwide, shows that the majority of
PGD children has normal psychomotor development and their parents do not
express high levels of parental stress.
Keywords:
Preimplantation genetic diagnosis, Genetic evaluation , Congenital anomalies, Psychomotor development , Parental stress
