Μελέτη της απόπτωσης σε καρκίνωμα στομάχου

Doctoral Dissertation uoadl:1307160 183 Read counter

Unit:
Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences
Deposit date:
2015-04-22
Year:
2015
Author:
Amptoulach Sousana
Dissertation committee:
Ν. Τσαβαρής, Ε. Πατσούρης, Ν. Καβατζάς
Original Title:
Μελέτη της απόπτωσης σε καρκίνωμα στομάχου
Languages:
Greek
Summary:
There is strong evidence that tumor growth is not only a result of uncontrolled
cell proliferation but also of decreased apoptosis. Caspase-3 is a member of
interleukin-1 beta-converting enzyme which is involved in the induction of
apoptosis. Data on the expression of caspase-3 in patients with gastric cancer
and its association with patient outcome are somewhat contradictory. We aimed to
investigate the potential relation of the expression of caspase-3 protein with
response to therapy and overall survival in patients with advanced noncardia
gastric cancer. Tumor tissue samples collected from 359 consecutive patients
with gastric cancer stage IV were retrospectively analyzed for the expression
of caspase-3 in the primary tumor. The DNA apoptotic index assessed by the
terminal
deoxynucleotidyl transferase-mediated deoxyuridine triphosphate- biotin nick
end labeling method. All patients were followed up until death. Caspase-3 was
expressed in 43.5 % of tumors. Caspase-3 expression compared to no expression
was related with a higher DNA apoptotic index
(p\0.05). In multivariate analysis, tumor expression of caspase-3 was found to
be an independent predictor of poor treatment response and survival (p\0.05).
Expression of caspase-3 in advanced gastric cancer is a predictor of poor
response to treatment and survival. Further studies are needed to fully
elucidate the prognostic value of caspase-3 expression in these patients.
Keywords:
TUNEL, Caspase-3, Apoptosis, Gastric cancer, Survival
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
238
Number of pages:
98
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