Summary:
Visfatin, is a recent identified adipokine secreted largely by the visceral fat
and related with important mechanisms of atherosclerosis, however the role of
visfatin remains unclear. The purpose of this study is to evaluate the
influence of rosuvastatin treatment and physical exercise on serum
concentrations of visfatin, sirtuin 1, total and HMW (High Molecular Weight)
adiponectin, in a hyperlipidemia-atherosclerosis animal model.
Thirty five C57bl/6 mice were randomly divided into the following four groups:
A: standard chow, B: atherogenic diet, C: atherogenic diet and training on a
treadmill, D: atherogenic diet, training on a treadmill, and rosuvastatin
administration. The experiment duration was 12 weeks. Blood samples were
collected from each mouse at the following times: 0, 8 weeks of treatment, and
at the end of the treatment period (12 weeks).
Training has increased HDL-cholesterol levels, although statin in combination
with training led to significant improvement of the lipid profile. Training has
also reduced visfatin, total adiponectin and HMW adiponectin levels. The
rosuvastatin and training combination has reduced visfatin, sirtuin 1, total
adiponectin and HMV adiponectin levels. The reduction of visfatin and sirtuin 1
levels by the combination of training-statin, may represent a potential
antiatherogenic effect.
Keywords:
Visfatin, Atherosclerosis, Visceral fat, Rosuvastatin, Physical exercise