Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences

2014-12-19

2014

Βασιλείου Παναγιώτης

Ευαγγελία Κουσκούνη, Νικολέττα Ιακωβίδου,Γεώργιος Τρουπής

Μελέτη της δράσης της ερυθροποιητίνης σε χοίρειο μοντέλο κοιλιακής μαρμαρυγής

Greek

Administration of erythropoietin in a swine model of ventricular fibrillation induced cardiac arrest

In addition to its role in the endogenous control of erythropoiesis,
recombinant human erythropoietin (rh-EPO) has been shown to exert tissue
protective properties in various experimental models. However, its potential
role in the cardiac arrest (CA) setting has not yet been sufficiently
elucidated and only limited evidence exists regarding the possible role of
rh-EPO in the CA setting. The purpose of our study was to evaluate the effect
of rh-EPO administration in an experimental pig model of ventricular
fibrillation (VF)-induced CA. The primary goal of our study was to investigate
whether rh-EPO exerts any beneficial effect on ROSC (Return of Spontaneous
Circulation) rates, while the secondary aim was to assess its impact in the
short-term basis of 24-hour and 48-hour survival and neurologic score.
VF was electrically induced in 20 piglets and maintained untreated for 8
minutes before attempting resuscitation. Animals were randomized to receive
rh-EPO (5000 IU/kg, EPO group, n=10) immediately before the initiation of chest
compressions, or to receive 0.9% NaCl solution instead (control group, n=10).
Endpoints of the experiment were defined as either asystole or ROSC.
Compared with controls, the EPO group had higher rates of ROSC (100% vs 60%,
p=0.011), and higher 24h and 48-h survival (100% vs 40%, p=0.001). Diastolic
aortic pressure (DAoP) and coronary perfusion pressure (CPP) during
cardiopulmonary resuscitation (CPR) were significantly higher in the EPO group
compared to the placebo group. EPO treated animals required fewer number of
shocks in comparison with animals that received normal saline (p=0.04).
Furthermore, the neurologic alertness score was higher in the EPO group
compared to placebo at 24 (p=0.004) and 48 hours (p=0.021).
Administration of rh-EPO in a pig model of VF-induced CA just before
reperfusion facilitates ROSC and improves survival rates as well as hemodynamic
variables.

Cardiac arrest, Erythropoietin

Yes

180-183

Yes

319

183

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https://pergamos.lib.uoa.gr/uoa/dl/object/1307177