Predictive value of biochemical marker adam -12 at first trimester of pregnancy for hypertension and intrauterine growth restriction

Doctoral Dissertation uoadl:1308263 213 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2015-03-13
Year:
2015
Author:
Κασίμης Χαρίλαος
Dissertation committee:
Κασσάνος Δημήτριος Καθηγητής
Original Title:
Συσχέτιση του βιοχημικού παράγοντα ADAM 12 στο πρώτο τρίμηνο της κύησης με υπέρταση και καθυστέρηση της ενδομήτριας ανάπτυξης
Languages:
Greek
Translated title:
Predictive value of biochemical marker adam -12 at first trimester of pregnancy for hypertension and intrauterine growth restriction
Summary:
SUMMARY

Purpose: Delineate whereas ADAM-12 levels at first trimester of pregnancmay be
used as marker for hypertension-preeclampsia and IUGR.
Materials & Methods: It is a case control study. Serum ADAM 12 of women
presenting for routine assessment of risk for chromosomal abnormalities at 11+0
to 13+6 weeks of gestation was measured. The study group comprised of 98
pregnancies that subsequently developed gestational hypertension(PIH) or
preeclamsia(PE) or small for gestational age fetuses(SGA), and were compared to
100 uncomplicated pregnancies.
Results: There was no statistically significant difference of mean log MoM of
ADAM12 between control group and the group that consisted of all women with
complicated pregnancy (PE, PIH and SGA). ADAM12 levels in women who developed
PE during pregnancy were significantly lower than in women of control group
(mean log MoM: 0.109 vs 0.008, p=0.010). Similarly, ADAM12 levels in women who
developed PE and/or PIH were significantly lower than in women of control group
(mean log MoM: 0.066 vs 0.008, p=0.015). There was no significant difference of
ADAM12 levels between controls and pregnancies with SGA fetuses.
Conclusion: Maternal serum levels of ADAM-12 at the first trimester are
significantly lower in women who later develop preeclampsia and hypertantion
when compared with women with uncomplicated pregnancies.
Key words: ADAM12, preeclampsia, hypertension, biochemical marker Content:
Maternal serum levels of ADAM-12 at the first trimester are significantly lower
in women who later develop preeclampsia.
Keywords:
ADAM -12, Preeclampsia , Hypertension , Biochemical marker , IUGR
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
70
Number of pages:
106
File:
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