Correlation of endogenous sex hormones with depressive symptomatology of women in menopause.

Doctoral Dissertation uoadl:1308273 102 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2014-12-18
Year:
2014
Author:
Μπούζιου Γεωργία
Dissertation committee:
Ειρήνη Λαμπρινουδάκη Αναπληρώτρια Καθηγήτρια, Κωνσταντίνος Πανουλής Επίκουρος Καθηγητής, Λέων Αραβαντινός Επίκουρος Καθηγητής.
Original Title:
Συσχέτιση των ενδογενών ορμονών του φύλου με την καταθλιπτική συμπτωματολογία των γυναικών σε εμμηνόπαυση.
Languages:
Greek
Translated title:
Correlation of endogenous sex hormones with depressive symptomatology of women in menopause.
Summary:
The objective of the study was to investigate the potential influence of
endogenous sex hormones to depressive symptomatology,in Greek postmenopausal
women. The study assessed 207 postmenopausal women, of which 48 were users of
HT and 159 were not. Endogenous sex hormones concentrations were determined.
Presence and severity of psychological and depressive symptoms were evaluated
by Zung Depression scale, general psychopathology SCL-90-R scale, Greene's
Climacteric Scale, Utian Quality of Life Scale (UQOL).
Linear regression analysis results showed that FSH levels correlated negatively
with scoring in obsessive/compulsive symptoms while free estrogen index and
intensity of vasomotor symptoms affected positively the score in depression.
Free androgen index affected positively the score in anxiety, hostility and
psychoticism. E2/T ratio showed a positive effect on occupational and emotional
quality of life, the latter correlated negatively with scoring in Greene scale.
Menopausal symptoms and confounding factors - other than exercise - have a
negative impact on quality of life.
Conclusions: Increased androgenism and vasomotor symptoms are associated with
increased incidence of psychological and depressive symptoms in postmenopausal
women. Serum estradiol levels are important hormonal predictors of quality of
life in relation to health and sex life. Apart from hormones’absolute
concentrations, E2/T ratio independently affects the results of quality of
life, indicating the importance of peripheral estrogen production after
ovaries’ aging.
Keywords:
Menopause, Depression, Endogenous sex hormones, Quality of life, Hormone therapy
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
468
Number of pages:
229

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