Unit:
Τομέας Υγείας - Μητέρας - ΠαιδιούLibrary of the School of Health Sciences
Author:
Γεωργιόπουλος Γεώργιος
Dissertation committee:
Ζακόπουλος Ν., Λαμπρινούδη Ε.,Πανουλής Κ.
Original Title:
Συσχέτιση των ορμονών του φύλου με αγγειακούς δείκτες πρώιμης αθηρωμάτωσης σε υγιείς μετεμμηνοπαυσιακές γυναίκες
Translated title:
Αssociation of sex hormones with vascular markers of subclinical atherosclerosis in apparently healthy postmenopausal women
Summary:
Introduction: Accelerated atherosclerosis may be observed in postmenopausal
women. We sought to assess the associations between circulating endogenous sex
hormones and multiple endpoints of subclinical atherosclerosis in a relevant
Greek population.
Methods: Biochemical, hormonal and vascular parameters were measured in 411
healthy postmenopausal women with risk factors. All subjects (n=158) who
consented for re-evaluation and had completed their first annual visit were
re-examined.
Results: Free Androgen Index(FAI) was an independent predictor of functional
surrogate markers of atherosclerosis and offered incremental and
reclassification value over traditional risk factors or Heartscore(HS) for the
presence of arteriosclerosis. FAI predicted short-term changes in hemodynamic
parameters and HS. FAI was superior over alternative androgenicity indicators
for predicting indices of atherosclerotic disease. Prolactin also predicted
short-term changes in hemodynamic parameters and cardiovascular risk. Women who
exceeded the decade after the menopausal transition presented most of the
adverse associations highlighted above.
Conclusions: Increased androgenicity in postmenopausal women is associated
with multiple manifestations of subclinical atherosclerotic disease. Additional
mechanisms such as the pleiotropic effects of prolactin and the duration of
menopause could modify the progress in subclinical atherosclerosis. Further
prospective studies are warranted to explore associations of endogenous sex
hormones with clinical relevant cardiovascular events in postmenopausal women.
Keywords:
Atherosclerosis, Menopause, Surrogate markers, Hormones, Endogenous
Number of references:
437
Number of pages:
XXVI, 285
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