Unit:
Τομέας Βασικών ΕπιστημώνLibrary of the School of Health Sciences
Author:
Καραβιτάκης Μάρκος
Dissertation committee:
Καθ. Μ. Κουτσιλιέρης, Καθ. Π. Σκανδαλάκης, Αν. Καθ. Χ. Κόνσουλας, Αν. Καθ. Ε. Κοτσιφάκη, Επ. Καθ. Α. Αρμακόλας, Επ. Καθ. Κ. Μαυραγάνη, Επ. Καθ. Α. Φιλίππου
Original Title:
Το μοντέλο έκφρασης των υποδοχέων σωματοστατίνης, Kiss-1 και του υποδοχέα GPR54 στον καρκίνο της ουροδόχου κύστης
Summary:
In the present study we evaluated the expression pattern of Kiss1, GPR54 and of
the somatostatin receptors 1-5 (SSTRs) in bladder cancer. We examined 46 tissue
samples from normal and cancerous urothelium. There were no expression of Kiss
1 and GPR54. SSTR1 was expressed in 24 samples, SSTR2 in 15 samples, SSTR3 in
23 samples, SSTR4 in 16 samples and SSTR5 in all but one. Bladder cancer tissue
samples expressed lower levels of SSTR3 (p=0.03). In 8 cases SSTR5 was the only
SSTR expressed, in 8 cases there was coexpression between SSTR5 with another
SSTR, in 17 cases there were coexpression of more than 2 SSTRs while in one
case there were no expression of SSTR. Among the 8 cases with coexpression
between 2 SSTRs, there were only 3 recurrence and there was no a case with
muscle invasive disease (p=0.05). Our results demonstrate for the first time
that there is expression of SSTRin bladder cancer and normal bladder
urothelium. Further studies are required to evaluate the significance of our
findings.
Keywords:
Bladder cancer, Kisspeptin, Somatostatin receptor, Receptor GPR54, Urothelium
Number of index pages:
32
Number of references:
564
