Φαρμακοκινητικές ιδιότητες και αντιμικροβιακή δράση εισπνεόμενης κολιστίνης σε ασθενείς με λοίμωξη κατώτερου αναπνευστικού στη μονάδα εντατικής θεραπείας

Doctoral Dissertation uoadl:1308385 324 Read counter

Unit:
Τομέας Κλινικοεργαστηριακός
Library of the School of Health Sciences
Deposit date:
2015-06-22
Year:
2015
Author:
Αθανασά Ζωή
Dissertation committee:
Αθανάσιος Τσακρής, Γεώργιος Μπαλτόπουλος, Παύλος Μυριανθεύς
Original Title:
Φαρμακοκινητικές ιδιότητες και αντιμικροβιακή δράση εισπνεόμενης κολιστίνης σε ασθενείς με λοίμωξη κατώτερου αναπνευστικού στη μονάδα εντατικής θεραπείας
Languages:
Greek
Summary:
The aim of the study was to evaluate inhaled colistin pharmacokinetic
properties and the effectiveness of inhaled colistin monotherapy in patients
with ventilator-associated tracheobronchitis.
Our pharmacokinetic study included 20 patients. After inhaled colistin
administration the median (25-75% interquartile range) values of colistin
concentrations in epithelial lining fluid was 6,7 (4,8-10,1), 3,9 (2,5-6,0)
and 2,0 (1,0-3,8) μg/ml at 1,4 and 8 hours respectively, and almost fivefold
higher than those in serum. However the median value of colistin concentration
in epithelial lining fluid at 8 hours was lower than determined breakpoints for
Gram-negative bacteria.
The effectiveness of monotherapy with inhaled colistin was evaluated in 12
patients. During treatment 9 patients showed a favorable clinical response,
while 8 of the 9 cured patients showed a favorable microbiological response.
Keywords:
Pneumonia, Trachiobronchitis, Inhaled colistin, Pharmacokinetics
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
170
Number of pages:
138
File:
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