Τομέας Υγείας - Μητέρας - ΠαιδιούLibrary of the School of Health Sciences
Καθηγητής Δημήτριος Καφετζής ( επιβλέπων), Μαρίζα Τσολιά ,Βασιλική Παπαευαγγέλου
Χορήγηση αργινίνης σε πρόωρα νεογνά και μέτρηση της καλπροτεκτίνης των κοπράνων ως δείκτη φλεγμονής του εντέρου
Objective: To determine the potential effect of oral L-arginine supplementation
on intestinal inflammation in very low birth weight (VLBW) preterm infants, as
estimated by faecal calprotectin levels and the incidence and severity of NEC.
Study design: The study enrolled 83 VLBW neonates with birth weight 1500 g
and gestational age 34 weeks. In this double blind study 40 neonates received
daily oral L-arginine supplementation of 1.5mmol/Kg/day between the 3rd and
28th day of life and 43 neonates received placebo. Stool samples were collected
on days 3, 14 and 28 and calprotectin was measured by ELISA. Diagnosis and
classification of NEC were done according to modified Bells’ criteria.
Results/Conclusions: Faecal calprotectin values significantly decreased with
increasing postnatal age in both groups (p=0.032) but this is not related to
arginine supplementation. No adverse effects were observed in neonates
receiving arginine supplementation. The incidence of NEC stage III was
significantly lower in the arginine supplemented group (2.5% vs 18.6%,
p=0.030). The mortality of NEC is lower in the group receiving arginine
supplementation (0% vs 9.3%, p=0.045). Enteral L-arginine supplementation seems
to reduce the severity and mortality of NEC.
Necrotizing enterocolitis, Nitric oxide, Calprotectin, Arginine, Preterm neonates
Number of references:
File access is restricted only to the intranet of UoA.