Unit:
Τομέας ΠαθολογίαςLibrary of the School of Health Sciences
Dissertation committee:
Ιωάννης Νανάς, Μαρία Αναστασίου Νανά, Εμμανουήλ Αγαπητός, Ευστάθιος Ηλιοδρομίτης, Χριστίνα Ρούτση, Δέσποινα Σανούδου, Αναστάσιος Φιλίππου
Original Title:
Χρόνια καρδιακή ανεπάρκεια και μυοπάθεια σκελετικού μυός΄ Επιδράσεις του προγράμματος αποκατάστασης
Translated title:
Chronic heart failure and skeletal muscle myopathy' Effects of excercise training
Summary:
Background: Patients with chronic heart failure (CHF) present skeletal muscle
abnormalities. Aim of this study was to evaluate the effect of exercise
training and left ventricle assist device (LVAD) implantation on skeletal
muscle myopathy.
Methods: Eight HF patients were evaluated with cardiopulmonary exercise test
(CPET) and respiratory function tests at 1, 3 and 6 months after LVAD. Also, 13
CHF patients participated at a rehabilitation program of 36 sessions. Patients
performed CPET and skeletal muscle biopsies before and after the completion of
the rehabilitation program.
Results: The inspiratory muscle strength and aerobic capacity increased after
LVAD implantation. Patients after exercise training improved their exercise
capacity and a skeletal muscle hypertrophy was noted. A significant 21%
increase of type I fibers was observed and an 24% increase of capillary to
fiber ratio (p=0.005). An increased expression of the IGF-1 (Insulin-like
growth factor 1) transcripts (Ea, Eb, Ec) was found following the exercise
training. The increase of muscle fibers’ CSA correlated with the increase of
IGF-1Eα (r=0.62, p=0.02) and IGF-1Εb (r=0.65, p=0.02).
Conclusions: LVAD support induces an improvement of respiratory muscles.
Exercise training could possibly reverse skeletal muscle myopathy of CHF
patients.
Keywords:
Heart failure, Myopathy, Excercise, Left ventricular assist device, Insulin like growth factor-1
Number of references:
157
