Mελέτη λιποκυτοκινών στην παιδική παχυσαρκία

Doctoral Dissertation uoadl:1308514 113 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2014-03-17
Year:
2014
Author:
Μεθενίτη Δήμητρα
Dissertation committee:
Καθηγητής Γεώργιος Χρούσος
Original Title:
Mελέτη λιποκυτοκινών στην παιδική παχυσαρκία
Languages:
Greek
Summary:
OBJECTIVE: Hypovitaminosis D has been associated with adult as well as
childhood obesity.
Retinol-–binding-–protein-–4 (RBP-–4) and Neutrophil Gelatinase-–associated
Lipocalin (NGAL) are
altered in obese individuals. The aim of this study was to examine circulating
25-–(OH) Vitamin
D (25-–(OH) D) concentrations according to BMI and its associations with RBP-–4
and NGAL in
female children and adolescents. DESIGN: Seventy-–nine (79) children, aged
8-–16 years, were
studied and divided into four groups: 19 control (BMI z-–score range -–2.15 -–
1.24), 20 overweight
(1.34 – 2.49), 20 obese (2.50 – 2.87) and 20 ultra-–obese (3 -– 4.37). Patients
were derived from a
Pediatric Obesity Clinic. Plasma 25-–(OH) D, RBP-–4 and NGAL concentrations
were measured
with specific assays. RESULTS: Plasma 25-–(OH) D concentrations were decreased
signifi-–
cantly in the ultra-–obese (p=0.005) and marginally in the obese group (p=0.05)
compared to
the control group. In the entire BMI range, Spearman correlations revealed
strong positive
associations between 25-–(OH) D and RBP-–4 (r=0.349, p=0.002) and between 25-–
(OH) D and
NGAL (r=0.338, p=0.003). CONCLUSIONS: 25-–(OH) D is deficient in a clinical
population
of obese female children and adolescents, whereas in the entire BMI range 25-–
(OH) D is as–
sociated with RBP4 and NGAL concentrations. Longitudinal studies are needed to
reveal the
role of these associations in metabolic alterations related to childhood and
adolescent obesity and associated metabolic morbidities.
Keywords:
Children, Vitamin-–D, NGAL, Obesity, RBP-–4
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
148
Number of pages:
87

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