Τομέας Βασική Επιστήμη Βιολογίας Στόματος
Βιβλιοθήκη Οδοντιατρικής

2015-04-03

2014

Τσιλιγκρού Ιωάννα

Βασίλης Πανής, Φοίβος Μαδιανός, Κωνσταντίνος Τόσιος

Ανοσοϊστοχημική μελέτη της έκφρασης του συνδεόμενου με τον πυρήνα μεταγραφικού παράγοντα-2 (Runx-2), της μορφογενετικής πρωτεΐνης του οστού - 2 (BMP-2) και της πρωτεΐνης προσκόλλησης της οστεΐνης (CAP) σε περιφερικά οστεοποιά ινώματα που εκφράζουν ίνες οξυταλάνης

Greek

AIM: To investigate the immunohistochemical expression of runt related
transcription factor 2 (Runx-2), bone morphogenetic protein-2 (BMP-2), and
cementum attachment protein (CAP) in oxytalan-positive POF, in order to
establish the use of POF as an in vivo model for the study of the periodontal
ligament.
MATERIALS AND METHODS: Thirty tumors that presented clinical and histologic
features of peripheral ossifying fibroma (POF), as well as oxytalan fibers,
were included in the study. Immunohistochemical expression of Runx-2, BMP-2 and
CAP was evaluated by light microscopy.
RESULTS: Runx-2, BMP-2 and CAP were abundantly expressed by POFs; twenty two of
thirty tumors expressed positive staining for Runx-2, twenty six tumors for
BMP-2 and twenty five tumors for CAP. The expression of Runx-2 was abundant in
POFs where bone was histologically present (p=0.04) and of BMP-2 in POFs where
dystrophic calcifications were present (p=0.03).
CONCLUSION: It is suggested that oxytalan-positive POFs, purportedly
originating from the periodontal ligament, express molecules that are specific
to bone and cementum (Runx-2, BMP-2), or cementum only (CAP). Thus, the cell
populations present in the lesion belong to the mineralized-tissue-forming cell
lineages, the cementoblastic or osteoblastic lineage.

Osteogenesis, Cementogenesis, Peripheral ossifying fibroma

No

0

Yes

462

250

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1308568