Unit:
Τομέας Βασική Επιστήμη Παθοβιολογίας ΣτόματοςΒιβλιοθήκη Οδοντιατρικής
Dissertation committee:
Παπαδογεωργάκης Νικόλαος , Νικητάκης Νικόλαος, Αλεξανδρίδης Κωνσταντίνος
Original Title:
Η έκφραση του επαγωγέα σήματος και ενεργοποιητή της μεταγραφής(STAT1) και η συσχέτισή του με τη σταδιοποίηση, το βαθμό διαφοροποίησης και την επιβίωση στο ακανθοκυτταρικό καρκίνωμα της στοματικής κοιλότητας
Summary:
Purpose: To estimate whether the immunohistochemical (IHC) expression patterns
of the tumor suppressor gene signal transducer and activator of transcription-1
(STAT1) and its active phosphorylated form (PSTAT1) serve as potential
prognostic and predictive markers in patients with oral squamous cell carcinoma
(OSCC).
Patients and Methods: STAT1 and PSTAT1 protein expressions were examined
immunohistochemically in OSCC tumor tissues and adjacent normal mucosa from 49
patients who underwent primary surgery. The IHC scores were correlated with all
available clinicopathologic parameters that were obtained from a maximum of 7
years of follow-up, including survival and response to adjuvant therapy
treatment.
Results: There was a shift toward lower percentages of cells with STAT1 (P <
.014) and PSTAT1 (P < .001) expression detected in OSCC tumors compared with
adjacent normal tissue sites. No association with patients’ clinicopathologic
characteristics was shown However, for the group of patients who received
adjuvant chemotherapy, increased PSTAT1 intensity of staining in OSCC tumors
was strongly associated with better overall survival (P = .008).
Conclusions: This is the first study to concurrently evaluate STAT1 and PSTAT1
IHC expression patterns and their prognostic significance in patients with
OSCC, highlighting the potential role of PSTAT1 as a biomarker in therapeutic
decision making. Large prospective studies are needed to verify these findings.
Keywords:
STAT1, PSSTA1, Survival, Oral cancer, OSCC
Number of references:
188