Unit:
Τομέας ΙΙ [Οργανική Χημεία – Οργανική Χημική Τεχνολογία – Χημεία Τροφίμων]Library of the School of Science
Author:
Παπακωνσταντίνου Βασιλική
Dissertation committee:
Κωνσταντίνος Α. Δημόπουλος Καθηγητής (Επιβλέπων) , Σμαραγδή Αντωνοπούλου Καθηγήτρια, Ελισάβετ Φραγκοπούλου Επίκ. Καθηγήτρια
Original Title:
Επίδραση της Αντιρετροϊκής Αγωγής στο Μεταβολισμό του Παράγοντα Ενεργοποίησης των Αιμοπεταλίων
Translated title:
The Effect of Antiretroviral Therapy on the Metabolism Of Platelet Activating Factor
Summary:
The progress of antiretroviral therapy has converted HIV infection from a death
sentence into a chronic disease. Eventhought, numerous factors, related either
to the virus itself or the antiretroviral therapy, are responsible for the
lower life expectancy and the higher inflammatory markers of HIV patients
compared to the average population. This condition has been defined as immune
activation and is responsible for many pathological conditions namely “non-AIDS
morbidities” such as malignancies, cardiovascular and renal disease. The
inflammatory background of the above pathological conditions has raised
questions about the in vivo effect of the antiretroviral therapy on the
metabolism of Platelet Activating Factor (PAF), the most potent inflammatory
mediator. In order to elucidate this effect, 50 male, asymptomatic and naive
HIV-infected patients have been recruited and divided into 5 groups according
to their antiretroviral therapy; Group A received tenofovir-DF/emtricitabine/
efavirenz, Group B received abacavir/lamivudine/ efavirenz, Group C received
tenofovir-DF/emtricitabine/ atazanavir-r, Group D received abacavir/lamivudine/
atazanavir-r and Group N was the positive control group consisted of the naive
patients. After 6 blood donations within 12 months, PAF levels and the specific
activity of PAF metabolic enzymes were defined in patients’ blood. The results
display the effect of antiretroviral therapy on PAF metabolism, having either
an inhibitory or an activating action. In addition, PAF seems to be implicated
in the immune activation as well in the non-AIDS morbidities. The present data
could trigger the research and development of antiretrovirals with
anti-inflammatory and especially anti-PAF actions in order to diminish chronic
activation and its harmful consequences during HIV infection.
Keywords:
Platelet Activating Factor, Inflammation, HIV-infection, Antiretroviral Therapy, non-AIDS morbidities
Number of index pages:
1-9
Number of references:
390
