Τομέας ΦΑΡΜΑΚΕΥΤΙΚΗΣ ΧΗΜΕΙΑΣ
Library of the School of Science

2012-03-22

2012

Φωτοπούλου Θεανώ

Γεώργιος Β. Φώσκολος Καθηγητής

Σχεδιασμός και σύνθεση πουρινικών αναλόγων που φέρουν ομάδες νιτρικών εστέρων. Φαρμακολογική μελέτη της καρδιοπροστατευτικής τους δράσης

Greek

The greatest advance in our understanding of the cell survival machinery was
the discovery of endogenous mechanisms of protection, which they termed,
Ischemic Preconditioning, (IPC) and Ischemic Postconditioning, (PostC). IPC and
PostC describe the cardioprotection obtained from applying transient episodes
of myocardial ischemia and reperfusion either before of after the index
ischemic event, respectively. Both mechanisms appear to recruit a similar
signaling pathway at time of myocardial reperfusion.
Here we report the design and synthesis of novel purine analogues bearing an
nitrate ester group at positions 6, 8, 9 of purine moiety as well as adenosine
derivatives, possessing structural features of adenosine receptor agonists,
with an attached nitrate ester group.
The new compounds were evaluated for their ability to trigger the beneficial
effect of IPC and PostC in vivo, in anesthetized rabbits, by means of
myocardial infarct size reduction. All the new analogues were administered
either before or after the sustained ischemic insult.
The novel compounds had a significant cardioprotective activity by means of
reducing infarct size, compared to control, IPC and PostC groups.

Purines, NO donors, Ischemic preconditioning agents, Ischemic postconditioning agents

No

0

Yes

168

208

File access is restricted.

https://pergamos.lib.uoa.gr/uoa/dl/object/1309419