Unit:
Τομέας Γενετικής και ΒιοτεχνολογίαςLibrary of the School of Science
Author:
Σαρίκα Ελένη-Λήδα
Dissertation committee:
Θεοχάρης Παταργιάς (επιβλέπων) Ομότιμος Καθηγητής Ε.Κ.Π.Α., Μιλτιάδης Τύπας Καθηγητής Ε.Κ.Π.Α. ,Εμμανουήλ Φραγκούλης Καθηγητής Ε.Κ.Π.Α.
Original Title:
Το σύστημα αντιμεταφοράς Na+/Li+ στα ερυθρά αιμοσφαίρια ινσουλινοεξαρτώμενων διαβητικών γυναικών και η σχέση του με την προεκλαμψία
Translated title:
Erythrocyte Na+-Li+ counter-transport activity in insulin dependent diabetic women with preexisting preeclampsia
Summary:
Aim of the study: To determine whether there is pathogenetic link between red
cells sodium–lithium counter-transport activity and digoxin-like immunoreactive
substances (DLIS) in plasma of insulin-dependent diabetic (IDDM) and
non-diabetic women with preexisting preeclampsia (PE). Our study also aimed to
investigate, if there is a possible genetic contribution in development of PE
in women with preexisting PE.
Subjects and methods: We studied Na+/Li+ CT activity in red cells and plasma
levels of DLIS in 12 IDDM women with preexisting PE (Group 1), 12 IDDM without
preexisting PE (Group 2) 23 non-diabetic women with preexisting PE (Group 3)
and 12 non-diabetic women with normal pregnancy (Group 4) at least 4 months
after delivery. We also examined the above factors in 23 parents of 13 women
with preexisting PE.
Results: Na+/Li+ CT activity was higher in Group 1 compared to Group 2 (mean ±
SEM 0.316 ± 0.05 vs 0.190 ± 0.02 mmol/LRBC/hr p < 0.05) and in Group 3 compared
to Group 4 (0.365 ± 0.004 vs 0.168 ± 0.01 mmol/LRBC/hr, p < 0.01). Plasma
levels of DLIS were higher in Group 3 compared to Group 4 (0.727 ± 0.189 vs
0.295 ± 0.066 ng/ml; p < 0.05); there was no statistically significant
difference between the two diabetic groups. In Groups 1 and 3, Na+/Li+ CT
activity was correlated to the plasma levels of DLIS (r = 0.927; p < 0.001 and
r = 0.485; p < 0.05 respectively).
Conclusion: Increased Na+/Li+ CT activity and increased plasma levels of DLIS
may contribute to PE in IDDM and non-diabetic women.
Keywords:
Sodium-Lithium countertransport, Preeclampsia, Gestational Diabetes, Hypertension, Endogenous inhibitors of Na+/K+ ATP ase
Number of references:
106
