Development of methods for the determination of veterinary drugs in food matrices by liquid Chromatography – mass spectrometry

Doctoral Dissertation uoadl:1309605 566 Read counter

Unit:
Τομέας Ι [Θεωρητική Χημεία – Φυσικοχημεία – Ανόργανη Ανάλυση – Ενόργανη Ανάλυση – Οργανολογία – Χημική Μηχανική (Εφαρμ. Φυσικοχημεία)]
Library of the School of Science
Deposit date:
2015-02-16
Year:
2015
Author:
Δασενάκη Μαριλένα
Dissertation committee:
Νικόλαος Θωμαΐδης Αναπλ. Καθηγητής (Επιβλέπων), Μιχαήλ Κουππάρης Καθηγητής, Αναστασία Χισκιά Ερευνήτρια Α΄
Original Title:
Development of methods for the determination of veterinary drugs in food matrices by liquid Chromatography – mass spectrometry
Languages:
English
Translated title:
Ανάπτυξη μεθόδων προσδιορισμού κτηνιατρικών καταλοίπων σε τρόφιμα ζωικής προέλευσης με υγροχρωματογραφία – φασματομετρία μαζών
Summary:
The possible presence of veterinary drug residues and other contaminants in
edible tissues and even food products is one of the key issues for food safety
which arouses great public concern. The main objective of this thesis was the
development of sensitive, selective, robust and effective analytical methods
for the determination of veterinary drugs in food of animal origin using liquid
chromatography hyphenated with mass spectrometric techniques.
Initially, an extended review of the veterinary drug classes and the existing
methodologies for their determination is presented. The experimental section
of the thesis is constituted of four parts: (1) Multi-residue determination of
seventeen sulfonamides and five tetracyclines in fish tissue using a
multi-stage LC-ESI-MS/MS approach based on advanced mass spectometric
techniques (Chapter 3), (2) Qualitative multi-residue screening methods for 143
veterinary drugs and pharmaceuticals in milk and fish tissue using Liquid
Chromatography Quadrupole-Time-Of-Flight Mass Spectrometry (Chapter 4), (3)
Multi-residue determination of 115 veterinary drugs and pharmaceutical residues
in milk powder, butter, fish tissue and eggs using Liquid Chromatography-Tandem
Mass Spectrometry (LC-MS/MS) (Chapter 5) and Multiresidue / Multiclass
Determination Of 76 Veterinary Drugs And Pharmaceuticals In Bovine Muscle
Tissue By Hydrophilic Interaction Liquid Chromatography-Tandem Mass
Spectrometry (HILIC-MS/MS) (Chapter 6).
It is our strong belief that these studies will constitute a step forward in
multiresidue veterinary drug analysis, providing rapid and reliable analytical
results.
Keywords:
Veterinary drugs, LC-MS/MS , LC-QTOF MS, Multi-residue methods, Food matrices
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
251
Number of pages:
252
document.pdf (3 MB) Open in new window