Unit:
Τομέας Βιολογίας Κυττάρου Και ΒιοφυσικήςLibrary of the School of Science
Dissertation committee:
Ισιδώρα Παπασιδέρη, Καθηγήτρια Κυτταρικής και Αναπτυξιακής Βιολογίας, Τμήματος Βιολογίας, ΕΚΠΑ
Original Title:
«HPV λοίμωξη και καρκίνος του τραχήλου της μήτρας»
Translated title:
«HPV infection and cervical cancer»
Summary:
The aim of this study was to detect and identify HPV types that appear in a
large sample of women from a wide age range, their incidence and mRNA from
E6/E7 oncogenes of high-risk HPV types (HPV-16,18,31,33,45) correlating this
data with cytology, smoking and oral contraceptives. The study group consisted
of a consecutive sample of 1145 women 14-70 years old. 44.7% of all women were
positive for HPV. HPV16 and HPV42 were the most frequent genotypes in total
samples followed by HPV53 and HPV51. HPV frequency increased as the severity of
cytological lesions was escalating. The higher prevalence of HPV infection was
observed in the 14-25 years old age group. Perhaps the most important figure is
the 3.6% of women who do not seem to harbour any of the five high risk types,
but the mRNA assay is positive for at least one type. Finally, a quite
significant relationship was found between tobacco use and the detection of at
least one HPV type. E6/E7 mRNA detection in women with normal cytology or low
grade lesions reflect the oncogenic activity of the above hrHPV types,
therefore it could be used as screening marker for better surveillance in this
subset of women.
Keywords:
HPV, Cervix, Genotyping, mRNA detection, Ε6/Ε7
Number of references:
248
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