Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2015-12-09

2015

Κατσάβη Μαργαρίτα

Τσελένη-Μπαλαφούτη Σ, Παυλάκη Α, Γακιοπούλου Χ.

Ανοσοιστοχημικοί δείκτες στην διάγνωση των όγκων των επινεφριδίων

Greek

The adrenal glands are distinguished into two parts, the cortex and the
medulla. The tumors of the adrenal gland, in recent years, are the most
commonly occurring tumors in humans. They can be either bening or malignant.
Tumors arising from the cortex include adenomas and carcinomas and tumors from
the medulla include the pheochromocytoma and neuroblastoma. Immunohistochemical
techniques have been used a lot and have provided valuable help in the
differential diagnosis of the adrenal tumors. The immunohistochemical panel is
used to assist in the differentiation and immunostaining with established
techniques. Even a negative reaction is a very useful result. The
diversification of tumors of the cortex of the medulla the main
immunohistochemical markers are chromogranin, calretinin and synaptophysin. In
most reported cases of adrenocortical carcinoma, cells showing positivity for
inhibin, melan-A, SF-1, VIM and cytokeratines mainly CK8 and CK18.
Neuroblastoma immunohistochemically differentiated from other tumors with
similar phenotype in help of neuronal specific enolase NSE, the chromogranin,
synaptophysin and the peptide hormone VIP. As a predictor of the adrenocortical
tumors used ki-67 antigen. These results are very useful as these indicators
help in differential diagnosis of tumors of the adrenal gland, in their
clinical behavior and any metastases.

Adrenal glands, Cortex, Medulla, Immunohistochemical markers, Pheochromocytoma

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310068