Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Περδικάρη Βικτώρια
Supervisors info:
Χριστόπουλος Παναγιώτης
Original Title:
Αποτελεσματικότητα χορήγησης ιβουπροφαίνης έναντι παρακεταμόλης στην αντιμετώπιση της πρωτοπαθούς δυσμηνόρροιας
Translated title:
Εffectiveness of ibuprofen versus paracetamol in the treatment of idiopathic dysmenorrhea
Summary:
Dysmenorrhea is defined as the painful form of menstruation. Two types of
dysmenorrhea are described as follows: The primary dysmenorrhea and the
secondary type.
The primary dysmenorrhea is not associated with any pathological condition of
the uterus or the endopelvic organs and occurs mainly in younger women. In
terms of pathophysiology, dysmenorrhea is to blame for the increased tone of
the uterine muscle during menstruation. The pain seems to be due either to the
increased sensitivity of the pain receptors in the prostaglandins or to uterus
ischemia.
The secondary or acquired dysmenorrhea is rather unusual before the age of 25
and the case is / (it is due to) an endopelvic organs disease. The most common
cause of secondary dysmenorrhea is endometriosis, myoma, ovarian cysts or
pelvic inflammatory disease.
Anti-inflammatory drugs such as ibuprofen and paracetamol are effective in
relieving the pain in dysmenorrhea (following the guidelines of international
Scientific Companies). More precisely, ibuprofen is a by-product of propionic
acid which has a significant anti-inflammatory, analgesic and antipyretic
effect mainly due to the inhibition of the composition of prostaglandins.
Paracetamol is a weak inhibitor of prostaglandin biosynthesis in the C.N.S,
fact which accounts for its analgesic antipyretic properties (similar to those
of acetilocalicylic acid).
In view of the above-mentioned, the very aim of the specific research is the
study of ibuprofen and paracetamol effectiveness in treating dysmenorrhea. More
specifically, the study focuses on the primary dysmenorrhea as the secondary
type is ruled out based on the criteria of elimination which is the existence
of endopelvic pathology
traced through the ultrasound as well as the medical history of women.
As far as the methodology of the project is concerned, the volume of the sample
consists of one hundred (100) women. Firstly, a questionnaire is handed out to
these women concerning their rating of dysmenorrhea before treatment. Later,
these 100 women are divided in two groups; Group A and
Group B. Group A is treated with ibuprofen during the first month and with
paracetamol during the second month. On the other hand, Group B is treated with
paracetamol during the first month and with ibuprofen during the second month.
The dosology of the medicines is the average suggested dosology for both
medicines. (dosage pattern is 1x3 for ibuprofen and 2x3 for paracetamol)
Following, the two medicines are compared in order to find out which of the two
was suggested by the women as a more effective analgesic in the treatment of
dysmenorrhea. The type of research is the cross over study and the duration of
collecting data will span for two months. Finally, the methology tool used are
special improvised questionnaires, the data of which are analysed with the
statistical package SPSS, version 24.
Keywords:
Dysmenorrhea, Primary dysmenorrhea , Secondary dysmenorrhea, Ibuprofen , Paracetamol
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