Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2014-01-31

2014

Πλοκαμάκη Ειρήνη

Αναπληρώτρια καθηγήτρια Α-Ε Κωνσταντινίδου

Απόπτωση και νεοπλάσματα. Γονιδιακή ρύθμιση, δείκτες και στοχευμένη θεραπεία.

Greek

Apoptosis is programmed cell death and is essential for the development and
survival of living organisms. It refers to a genetically defined, inside,
suicidal cell death mechanism, which is activated under a variety of
conditions, such as normal cell renewal in renewable tissues, immune
regulation, hormone deprivation and other factors, such as environmental risks.
Apoptosis can be executed through both the extrinsic and the intrinsic pathway,
where certain enzymes are activated, whereas many other proteins have also been
identified, except for the prominent apoptotic "players",caspases.
Disruption of this regulatory pathway can lead to various diseases such as
autoimmune diseases and cancers. We focus on apoptosis and the key role in the
growth of malignant tumors with the products of the p53 and Bcl-2 genes to be
the most relevant proteins for apoptosis and tumor growth . Inappropriate
apoptosis due to deregulation of cell death pathways, provides a plethora of
molecular checkpoints and apoptotic markers that can be targeted and modulated
as part of the therapeutic intervention.
Possible mechanisms of apoptosis and their role in cancer is under constant
research and study. Nevertheless, the ability of apoptosis to modulate the life
or death of a cell is also recognized for its immense therapeutic potential.
Understanding the mechanisms will give us a better and more complete insight to
the pathogenesis of cancer and will open new horizons for therapeutic
approaches and new targeted therapies.

Apoptosis, p53 protein, Bcl-2 proteins, Targeted therapy, Apoptotic markers

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310254