Unit:
Κατεύθυνση Διασυνδετική Ψυχιατρική και Απαρτιωμένη Φροντίδα Σωματικής και Ψυχικής ΥγείαςLibrary of the School of Health Sciences
Supervisors info:
Ρίζος Εμμανουήλ επίκουρος καθηγητής
Original Title:
Αρρυθμιολογικές διαταραχές με την χρήση αντικαταθλιπτικών φαρμάκων
Summary:
A number of different psychotropic agents have been associated with an
increased risk of cardiovascular disease, particularly tricyclic
antidepressants have been associated with iatrogenic prolongation of QT
interval; In addition a lot of new antidepressants such as citalopram have a
dosage-dependent result in prolongation of QT that must be taken into account
because of the possibility to cause malignant arrhythmias and sudden death.
Cardiotoxicity appears as a result of the overdosage while there are a few data
in therapeutical dosages. At cellular level, antidepressants inhibit
ion-channels and predispose to electrocardiographic disorders. Indeed this
possibility of malignant arrhythmias is not well associated with QT
prolongation, while all the antidepressants that inhibit HERG channels are not
prolonging QT interval. It is important to be considered all the risk factors
of cardiotoxicity and the drug interactions when an antidepressant is
prescribed.
Keywords:
Depression, Arrythmias, QT prolongation, Antidepressants, SSRIs
Number of references:
252
