Summary:
Background
Studies have shown that sepsis is closely correlated with biomarkers and
severity scoring systems but without having found someone as a reliable early
indicator.
Aim
The investigation of the role of biomarkers and severity scoring systems in
sepsis prognosis.
Material - Method
The study material consisted 122 critically ill patients who were hospitalized
in the Intensive Care Unit (ICU) of the General Hospital "Evangelismos" over 3
days. Of these, 71 patients experienced sepsis during their hospital stay. Data
collection included the measurement of biomarkers C-reactive protein (CRP),
procalcitonin (PCT) and white blood cells (WBC) and severity scoring systems
APACHE II and SOFA. The measurements took place in the day of admission to the
ICU. For data analysis methods were applied Mann-Whitney Test and multiple
logistic regression.
Results
There was a statistically significant difference in the levels of white blood
cells (WBC = 0,023) in patients who developed sepsis in the course of their
hospitalization, while since other biomarkers (CRP = 0,128, PCT = 0,069) showed
no statistically significant difference. From the severity scoring systems,
SOFA (p-value <0.001) was found increased in patients who later on experienced
sepsis. On multiple logistic regression, only SOFA prevailed as a strong
prognostic marker of sepsis (OR = 1.366, p-value <0.001, 95% CI: 1.157-1.613).
Conclusion
The values of white blood cells and SOFA the day of admission of critically ill
patients in the ICU, it seemed to be prognostic indicators of sepsis.
Keywords:
Biomarkers, Sepsis, ICU, Severity scoring systems
