Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences

2016-07-26

2016

Παγωνάκη Χρύσα

Καθηγητής Ανδρέας Χ. Λάζαρης

Γονιδιακή βάση του παγκρεατικού καρκίνου

Greek

The accumulation of genetic mutations leads to tumor growth. These genetic
changes activate protooncogenes by turning them into oncogenes or inactivate
tumor suppressor genes. Protooncogenes are called the genes that encode
proteins that promote cell cycle, survival and growth. In contrast, the
products of tumor suppressor genes inhibit the cell cycle and induce apoptosis.
Pancreas is a vital organ-gland of the digestive system. It consists of an
exocrine and an endocrine fate. The exocrine fate secretes digestive enzymes
and endocrine one secretes hormones.
Pancreatic cancer has a high mortality rate and poor prognosis with a 5-year
overall survival less than 5%. Pancreatic neoplasms are divided in exocrine and
endocrine ones based on the fate they arise from.
There are numerous genes whose mutations are responsible for pancreas cancer.
The most common are the oncogenes K-Ras, c-ErbB-2, myc and fos and the tumor
suppressor genes p53, Rb, p21 and Bax.

Genetic mutations, Pancreas, Pancreatic cancer, Genes, Oncogenes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310456