Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή Ιατρική
Library of the School of Health Sciences

2012-12-14

2012

Διαμαντή Κωνσταντίνα

Καθ. Π. Γ. Βλαχογιαννόπουλος, Καθ. Α. Γ. Τζιούφας,Λέκτορας Ε.Κ. Καψογεώργου

Δείκτες ενεργοποίησης κυτταρικών συστατικών του περιφερικού αίματος στο Σύνδρομο Αντιφωσφολιπιδίων

Greek

Antiphospholipid Syndrome (APS) is an autoimmune thrombophilia characterized by
thromboembolism and/or pregnancy morbidity. The underlying pathogenetic
mechanisms are yet unclear, but evidence exists that the circulating
autoantibodies (antiphospholipid antibodies, aPL) activate different cell
populations (platelets, endothelial cells, leukocytes) inducing a
procoagulant/proinflammatory phenotype. This study examined the levels of
different blood-borne soluble markers [Platelet Factor 4 (PF4), P-selectin,
matrix metalloproteinases (MMPs) -1, 3-, -9] of APS involved cellular
activation using enzyme-linked immunosorbent assays (ELISA). Plasma PF4 levels
were significantly higher in our group of APS patients with recurrent
thrombosis (n=16) than those with a sole event (n=18) and healthy donors (HD)
(n=22). Plasma P-selectin levels were significantly increased in primary APS
patients (n=14) compared with HD (n=24), Systemic Lupus Erythematosus (SLE)/APS
patients (n=22) and SLE patients (n=9). SLE/APS patients treated with aspirin
displayed significantly lower P-selectin levels. No difference in MMP-1 and
MMP-9 levels was found between APS patients and HD, while the difference
observed in MMP-3 levels is probably due to the influence of corticosteroids.
Finally, there was no correlation between the levels of the soluble markers
studied and the titer of aPL. Our data further highlight the importance of
platelet and endothelial cell activation in the pathogenesis of APS.

Antiphospholipid Syndrome, Cellular activation, Soluble biomarkers

No

0

Yes

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310473