Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2015-11-26

2015

Μπουλάς Παναγιώτης

Καθηγητής Κωνσταντίνος Ν. Συρίγος

Δείκτες καρκινικής καχεξίας σε ασθενείς με καρκίνο του πνεύμονα

Greek

Background. Cancer cachexia is a metabolic paraneoplastic syndrome diagnosed in
up to 60% of patients with lung cancer and associated with poor prognosis. It
is mainly characterized by weight loss, anorexia, weakness and sarcopenia, and
diagnostic criteria also include inflammation and nutritional biomarkers, such
as C-reactive protein (CRP).
Patients and Methods. We retrospectively reviewed the records of 46 patients
diagnosed with lung cancer and 42 controls (patients with no lung cancer or
other cancer type). We documented and evaluated patients' characteristics and
laboratory results associated with nutritional status and systemic
inflammation, in order to detect significant differences between the two
groups.
Results. Seventy-eight percent of lung cancer patients were men versus 43% in
the control group. Median age was 72.8 in lung cancer patients versus 71 years
in the control group. Adenocarcinoma was the most common histological type of
lung cancer. Lung cancer patients showed significantly higher CRP (p=0.000),
leukocyte (p=0.000) and thrombocyte levels (p=0.002), and significantly lower
albumin concentration (p=0.015) compared to controls. No significant
correlation was found between the two groups regarding hemoglobin,
erythrocytes, total proteins, creatine phosphokinase and lactate dehydrogenase.
Sixty-five percent of lung cancer patients fulfilled cancer cachexia criteria
regarding CRP (0,8 mg/dL) versus 24% of controls.
Conclusions. Lung cancer patients showed laboratory indications of more intense
systemic inflammation and worse nutritional status (increased CRP levels,
increased leukocyte and platelet counts, lower albumin concentration -
indications of cancer cachexia) at diagnosis compared to controls. Timely
diagnosis of cancer cachexia is essential for its early effective management.

Cachexia, Lung cancer, Weight loss, Inflammation, Nutrition

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310475