Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2014-07-22

2014

Σολδάτου Κυριακούλα

Καθηγητής Συρίγος Κωνσταντίνος

Δείκτες νεοαγγειογένεσης ασθενών με καρκίνο πνεύμονα

Greek

Background: Cancer growth and metastasis involve numerous biological steps,
including tumor cell invasion, motility, extracellular proteolysis, and
angiogenesis in both primary and metastatic sites. Angiogenesis is a complex
process, crucial for tumor biology. The ability of tumor to induce new
blood-vessel formation has been a major focus of cancer research over the past
decade. Each individual tumor develops a unique mechanism to induce
angiogenesis, and that activation of a particular angiogenic pathway suppresses
the evolution of alternative pathways. It is now known that members of the
vascular endothelial growth factor and angiopoietin families, mainly secreted
by tumor cells, induce tumor angiogenesis, whereas other endogenous angiogenic
inhibitors, including thrombospondin-1 and angiostatin, keep tumor in dormancy.
Aim: Our aim is to study whether the prognostic impact of vascular endothelial
growth factors (VEGFs) and receptors (VEGFRs), platelet-derived growth factors
(PDGFs) and receptors (PDGFRs) and fibroblast growth factor-2 (FGF-2) were
associated with tumor growth and metastasis in lung cancer.
Results: This article summarizes the recent research progress for some basic
angiogenic factors in tumor angiogenesis. Experimental and clinical evidence
has suggested that the process of tumor growth and metastasis depends on
angiogenesis or lymphangiogenesis and reported a negative prognostic impact of
angiogenic factors.
Conclusion: Unfortunately only a limited number of angiogenic factors are
evaluated, relative to the number that are known to affect angiogenesis and
limited is the knowledge of the mechanism that those factors act. Nevertheless
angiogenic factors seem to be prognostic indicators for tumor aggressiveness
and poor survival in lung cancer.

Lung neoplasms, Angiogenesis, Metastasis, VEGF

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https://pergamos.lib.uoa.gr/uoa/dl/object/1310477