Εκτίμηση μεταβολής των δεικτών τροπονίνης σε ασθενείς με σήψη

Postgraduate Thesis uoadl:1310921 227 Read counter

Unit:
Κατεύθυνση Μονάδες Εντατικής Θεραπείας-Καρδιολογική Νοσηλευτική
Library of the School of Health Sciences
Deposit date:
2015-04-24
Year:
2015
Author:
Παπαπαναγιώτου Μαρία
Supervisors info:
Αναπληρωτής καθηγητής Τσιούφης Κωνσταντίνος
Original Title:
Εκτίμηση μεταβολής των δεικτών τροπονίνης σε ασθενείς με σήψη
Languages:
Greek
Summary:
Introduction: Μyocardial dysfunction ιs often observed ιν sepsis and septic
shock. Τroponin is highly accurate in identifying septic patients with
myocardial damage due to sepsis.
The severity of the myocardial failure in sepsis has been shown to have
predictive value in relation to mortality.
Purpose:
The purpose of this study is to explore the relationship between the levels of
troponin and the seriousness of sepsis at ischemic and non ischemic patients.
Material and Methods. We have enrolled 31 men and 49 women in this study with a
mean age of 79 years. All demographic data were recorded on admission and blood
samples were taken in order to determine cardiac troponin, CRP, and lactic acid
and were estimated the possibility of death using the SOFA SCORE.
Results: 4% of our patients had a history of cardiovascular disease, 56% were
smokers and 55% had diabetes. The median troponin on admission was 0,1 ng / ml
and the median max troponin 0,5 ng / ml. Troponin values were associated with
SOFA, with the association being marginally of statistical significance (p =
0,09) Patients with a history of cardiovascular disease tended to have higher
troponin values (p = 0,06).The patients with higher SOFA score had higher
troponin values as well as their association being statistically significant (p
= 0,01) Additionally, troponin max had marginally significant positive
correlation with CRP (p = 0,07)
Conclusion. Peak levels of troponin in septic patients correlated with the
severity of sepsis measured with SOFA score. Our findings show that troponin
may be useful indicator of cardiac function in septic patients.
In addition to this, we could assume that the previous cardiological history,
which leads at increase of troponin, is correlated with higher mortality.
Keywords:
Troponin, Sepsis, C-reactive protein, Lactic acid, S.O.F.A score
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
188
Number of pages:
68
File:
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