Original Title:
Ενδοηπατική χολόσταση κύησης παράγοντες κινδύνου και περιγεννητικό αποτέλεσμα. Αναδρομική μελέτη 23 περιστατικών ενδοηπατικής χολόστασης της κύησης την τελευταία τριετία και ανασκόπηση της βιβλιογραφίας. Ποιοι είναι οι παράγοντες κινδύνου που προκαλούν την νόσο ή συμβάλλουν σε αυτήν; Πόσο σημαντική η επίδρασή της χολόστασης στο περιγεννητικό αποτέλεσμα;
Summary:
AIM: Determine the risk factors of ICP, their relationship based on
international references, the diagnostic methods, treatment and effect of the
disorder on perinatal morbidity.
MATERIALS AND METHODS: 23 women with ICP and 23 women with uncomplicated
pregnancy except from prematurity in the last three years. A statistical
analysis using Chi-squared test was applied to Apgar score in 1st minute,
neonates’ weight, presence of meconium, mother’s blood loss during labor,
total days of hospitalization of parturient-postpartum, neonates’
complications.
RESULTS: A statistically significant difference between the 2 groups
concerning the days of hospitalization of the parturient (p=0,007). No
statistically significant difference concerning Apgar score in 1st minute
(p=0,565), neonates’ weight (p=0,676), presence of meconium (p=0,219), mother’s
blood loss (p=0,327), total days of hospitalization of postpartum (p=0,180),
neonates’ complications (p =1,000).
CONCLUSIONS: ICP does not directly affect the fetal growth, nor appear to cause
coagulopathy. Burdens the NHS at least twice the days of hospitalization, as it
requires closer monitoring of the pregnancy. Concerning the complications of
the neonates, ICP does not appear to influence the presence in NICU >24 hours,
assisted nutrition, intubation, hyperbilirubinemia and administration of
surfactant. The results support the hypothesis that ICP causes acute effect in
embryo.
Keywords:
Intrahepatic cholestasis of pregnancy, Pruritus, Bile acids, Urseodeoxycolic acid, Perinatal outcome
