Κατεύθυνση Μοριακή και Εφαρμοσμένη Φυσιολογία
Library of the School of Health Sciences

2014-01-13

2013

Φωκά Βασιλική

Κοτσιφάκη Ελένη, αναπληρώτρια καθηγήτρια

Καρδιαγγειακή νόσος ως προδιαθεσικός παράγοντας για τη νόσο του alzheimer

Greek

Both neurodegenerative and cardiovascular diseases are conditions of high
prevalence in old age and the most common causes of cognitive decline
attributed to this period of time.
The Alzheimer’s disease and atherosclerosis are the main
representatives of these diseases. At first, their development was considered
to be independent but with parallel course which seems to have common links
capable of leading to cognitive impairment. Growing data provide evidence that
both diseases share common risk factors such as, hypertension, diabetes
mellitus and hyperlipidemia.
The aim of this thesis is to study the data that are represented so far
and are associated with the cardiovascular disease and the Alzheimer’s disease
and to evaluate the degree of co-existence between the two diseases. There was
an effort to correlate the various pathogenetic mechanisms of the two diseases
and the risk factors that may influence them.
Recent epidemiological studies and clinical data based on the findings
of patients suggest overlaps between Alzheimer’s disease and cerebrovascular
lesions. These lesions caused by cerebrovascular disease may result to
neurodegeneration and therefore magnify or even promote progression of
cognitive decline. Furthermore, there seems to be a common line between the two
diseases which may be caused by cerebral factors capable of instigating
neuronal damage and accumulation of distinct structures of Alzheimer’s
neuropathology.

Dementia , Cardiovascular disease, Alzheimer's disease, Atherosclerosis, Vascular dementia

No

0

Yes

113

82

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https://pergamos.lib.uoa.gr/uoa/dl/object/1312111