Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Καλογιάννη Παρασκευή
Supervisors info:
Αναπληρωτής Καθηγητής Ι. Ζέρβας, Αναπληρωτής Καθηγητής Γ. Μαστοράκος, Επίκουρος Καθηγητής Δ. Λάζαρης
Original Title:
Καταθλιπτικά συμπτώματα εγκυμοσύνης βιοχημικοί δείκτες και τρόπος περάτωσης τοκετού
Summary:
OBJECTIVE: The objective of the study was to examine the association of
maternal mid-pregnancy plasma CRH levels with prenatal depression and the
possible correlation between mid-pregnancy depression and the way of delivery
(caesarian section or vaginal delivery).
MATERIAL AND METHODS
-SUBJECTS: The patients of our study were collected during the last 2 years.
65 pregnant women at the gestational age of 26-29 weeks were included.
Exclusion criteria were high risk pregnancy and age under 18 years.
35 women delivered with vaginal delivery(1 st group) amd 30 with elective
caesarean section after 37 weeks of pregnancy(2nd group). All response in
• EPDS (Edinburg Postnatal Depression Scale)
• Athens Insomnia Scale
• Rosenberg Self-Esteem Scale (RSES)
A blood collection for hormones determination (ACTH-CRH-CORTISOLE) was
accomplished simultaneously with the completion of the questionnaire.
RESULTS: No correlation between mid-pregnancy depression and the way of
delivery (p-value 0,357>0,05), neither CRH levels (p-value 0,663>0,05), was
found in our study. The result of EPDS was independent from the results of the
Athens Insomnia Scale (p-value 0,2013>0,05) and Rosenberg Self-Esteem Scale
(p-value 0,334>0,05). Mid-pregnancy levels of ACTH (p-value 0,023<0,05) and
Cortisole (p-value 0,029<0,05) are associated with EPDS>12. Women who complete
their pregnancy with vaginal delivery have higher mid-pregnancy levels of ACTH
(p-value 0,001<0,005), Cortisole (p-value 0,011<0,05) and CRH (p-value
0,001<0,005). 54% of women have had mid-pregnancy score of EPDS>12 (range
13-17) while before delivery 94%. It seems that prenatal depression concerns
many pregnant women and has a strong correlation with stress biochemical
markers.
Keywords:
depression, pregnancy, CRH, delivery, cortisole
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