Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Supervisors info:
Αν. Καθ. Βλάχος Νικόλαος (επιβλέπων), Αν. Καθ. Μαστοράκος Γεώργιος, Καθ. Δοντά Ισμήνη
Original Title:
Μελέτη της επίδρασης της καμπεργολίδης και της Ν-ακέτυλο-κυστεΐνης στην αναστολή της ανάπτυξης ενδομητριωσικών εμφυτευμάτων σε πειραματικό μοντέλο ενδομητρίωσης. Μελέτη σε επίμυες του γένους Wistar.
Summary:
Aim: Endometriosis is a common cause of infertility between women of
reproductive age. Our study aimed to evaluate if a synergistic effect exists
between cabergoline (CAB) -a dopamine agonist- as an anti-VEGF factor and
N-acetyl-cysteine (NAC) -an antioxidant- on the reduction of endometrial
implant volume, in an experimental protocol of surgically induced endometriosis.
Methods: Forty Wistar rats were subjected to laparotomy and surgical induction
of endometriosis. After the evaluation of the implantation process, animals
were divided into 4 groups (control group, CAB group, NAC group and combination
of NAC and CAB group) and they received therapy for three weeks respectively,
followed by euthanasia. The number and mean volume of endometriosic implants
were recorded.
Results: The mean volume of the endometriosic implants was reduced after
treatment in CAB group and CAB+NAC group. No differences were found in NAC
group and in controls. In addition, synergistic effect of NAC with CAB was not
found.
Conclusions: CAB and NAC have an additive and not synergistic effect on the
reduction of the mean volume of endometriosic implants.
Keywords:
endometriosis, cabergoline, N-acetyl-cysteine, VEGF, oxidative stress
Number of references:
156
