Unit:
Κατεύθυνση Μοριακή και Εφαρμοσμένη ΦυσιολογίαLibrary of the School of Health Sciences
Author:
Χριστόπουλος Παναγιώτης
Supervisors info:
Καθ. Μιχάλης Κουτσιλιέρης
Original Title:
Μελέτη της έκφρασης των ισομορφών του IGF-1 σε καρκινικές κυτταρικές σειρές
Summary:
The importance of IGF-1 isoforms in cellular proliferation in muscle is well
known. In recent years, despite the fact many published data correlate isoforms
with several cancer types, there are still researchers which reject isoforms
existence.
Here we present a new tool for measurement expression levels, highly specific
to mRNA of IGF-1 isoforms. The results from 13 human cell lines (11 cancerous
and 2 normal) reveal a differential expression pattern depending on cell line.
In addition we present how this pattern changes under several treatments, where
the unique role of E peptide is revealed.
Keywords:
IGF-1 isoforms, IGF-1 Ea, IGF-1 Eb, IGF-1 cancer, MGF E peptide
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