Study of Pitx2+ interneurons throughout the mouse brain

Postgraduate Thesis uoadl:1312589 254 Read counter

Unit:
Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή Ιατρική
Library of the School of Health Sciences
Deposit date:
2016-10-19
Year:
2016
Author:
Τσαπάρα Γεωργία
Supervisors info:
Στεφανής Λεωνίδας, Καθηγητής Ιατρική Σχολή Αθηνών, Ζαγοραίου Λασκαρώ, Ερευνήρια Γ΄, ΙΙΒΕΑΑ, Πολίτης Παναγιώτης, Ερευνητής Γ΄, ΙΙΒΕΑΑ
Original Title:
Μελέτη των Pitx2+ διάμεσων νευρώνων στον εγκέφαλο του ποντικού
Languages:
Greek
Translated title:
Study of Pitx2+ interneurons throughout the mouse brain
Summary:
The rhythmic motor behaviors such us locomotion and respiration should be
adjusted so that an organism can cope with the diverse requirements in
different environments. The neural circuitry that organizes them needs to be
flexible. For
example, the rate of breathing should be modified depending on the mechanical
and metabolic requirements of different conditions or behavioral tasks. The
flexibility that is needed is provided partially by neuromodulatory systems
which alter the functional properties of the neurons and change the output of
the neural circuit. One such system is the neuromodulatory C-bouton synapse.
The C-boutons are large, cholinergic synapses onto motor neurons. In the spinal
cord they play a vital role as they increase the activity of motor neurons and
activation muscle as acetylcholine acts as a neuromodulator. We found that
C-boutons from neurons originate from neurons that are characterized from the
expression of the transcription factor Pitx2. In this study we demonstrated
Pitx2+ cholinergic interneurons neurons exist at the brainstem. In the motor
brainstem motor neurons there are C-boutons that originate from Pitx2+
cholinergic neurons. These results extend the existing findings on the
neuromodulation of C-bouton synapse throughout the Central Nervous System and
provide a new framework for the study of neuromodulation.
Keywords:
Brainstem, Pitx2+ interneurons, C-bouton synapse, Motor nuclei, Neuromodulation
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
59
Number of pages:
66
File:
File access is restricted only to the intranet of UoA.

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