Κατεύθυνση Έρευνα στην Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences

2014-01-08

2013

Λιάκου Χρυσούλα

Μαστοράκος Γεώργιος Αναπληρωτής Καθηγητής, Παπαιωάννου Νικόλαος Αναπληρωτής Καθηγητής, Τουρνής Συμεών Κλινικός Ιατρός

Μεταβολές των επιπέδων σκληροστίνης κατά το φυσιολογικό εμμηνορρυσιακό κύκλο.

Greek

ABSTRACT
BACKGROUND
Studies in postmenopausal women have proposed estrogens as potential regulators
of sclerostin production. which acts as an antagonist of canonical Wnt
signaling pathway. The present study, examines whether the fluctuations of sex
hormones throughout the menstrual cycle is accompanied by changes in serum
sclerostin levels and the relationship of the latter with changes in P1NP and
CTX serum levels.
METHODS
In this prospective observational clinical study, eighteen women, aged over 30
years, with a history of regular and spontaneous menstrual cycles, underwent
blood sampling every-other-day, from the first day of menstruation up to the
onset of the next menses, for the measurement of sex steroid serum levels
(estradiol, LH, FSH), sclerostin, P1NP, and CTX.
RESULTS
Sclerostin did not present statistically significant change across the
menstrual cycle. However, P1NP and CTX levels seemed to change significantly
across the cycle. Also, the percentage change of the CTX levels (negative sign)
from the LH peak until the middle luteal phase was negatively correlated with
estradiol ovulation levels.
CONCLUSION
Serum sclerostin levels did not seem to change during the normal menstrual
cycle, despite normal menstrual pattern of serum female hormones.

Sclerostin, Menstrual cycle , Estrogen, CTX, P1NP

Yes

X, XI, XII, XIII, XIV

Yes

179

XV, 99

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https://pergamos.lib.uoa.gr/uoa/dl/object/1312634