Τransmitted diseases with transfusion and new emerging pathogens

Postgraduate Thesis uoadl:1312644 344 Read counter

Unit:
Κατεύθυνση Θρόμβωση-Αιμορραγία-Ιατρική των μεταγγίσεων
Library of the School of Health Sciences
Deposit date:
2015-05-27
Year:
2015
Author:
Uwera Ariane
Supervisors info:
Ανθή Σ.Τραυλού
Original Title:
Μεταδιδόμενα νοσήματα με τη μετάγγιση και νέο αναδυόμενα παθογόνα
Languages:
Greek
Translated title:
Τransmitted diseases with transfusion and new emerging pathogens
Summary:
The uses of the history of blood donor and the FDA reports on serological tests
and nucleic acid testing (NAT) have significantly reduced the "infectious
window" for several transfusion-transmitted pathogens.
Currently, the transmission of human immunodeficiency virus, human T-cell
lymphotropic virus, hepatitis virus and West Nile virus are rare. The
prevalence of cytomegalovirus in the donor population is high and
cytomegalovirus infection can cause significant complications in
immunocompromised recipients of blood transfusion. Careful use of resources CMV
seronegative blood and leukapheresis products can prevent the occurrence of
more CMV infections in these patients. Currently, bacterial contamination of
platelet concentrates is the greatest risk of infectious disease in a blood
transfusion. Specialized procedures for collecting blood from donors can reduce
the risk of bacterial contamination of blood products.
The procedures for blood culture tests and substitutes tests used to detect
potentially contaminated blood products and derivatives with bacteria.
Particular attention is paid to emerging infectious diseases such as
Alzheimer's Creutzfeldt-Jakob, dengue fever, babesiosis, Chagas disease and
malaria.
The challenges relating to the detection and prevention of transmission of
these agents. Many methods are used to reduce the infectivity of blood and its
derivatives, there are many ways to further improve the safety of blood through
the progress screening of infectious diseases and pathogen inactivation methods.
Technological developments in diagnostic testing, vaccinations, inactivation of
pathogens and the vigilance of screening of blood donors have significantly
reduced the risk of transmission of pathogens via blood transfusion.
Nevertheless, still reported infections and deaths associated with transfusion,
while emerging pathogens continue to represent a growing threat to the blood
supply. This threat is even greater in patients with blood disorders, which are
transfused continuously and require safe blood products.
Keywords:
Transmitted diseases, Tranfusion , Emerging pathogens
Index:
No
Number of index pages:
0
Contains images:
No
Number of references:
29
Number of pages:
71
File:
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