Metaplastic carcinomas of the breast

Postgraduate Thesis uoadl:1312650 262 Read counter

Unit:
Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences
Deposit date:
2014-10-02
Year:
2014
Author:
Μυλωνά Νεκταρία
Supervisors info:
Επίκουρη καθηγήτρια Αφροδίτη Νόννη
Original Title:
Μεταπλαστικά καρκινώματα μαστού
Languages:
Greek
Translated title:
Metaplastic carcinomas of the breast
Summary:
Metaplastic breast carcinoma is a rare form and occurs only in between 0.2% and
5% of breast carcinoma patients. Metaplastic carcinoma of the breast
constitutes a heterogeneous group of neoplasms, which has epithelial and/or
mesenchymal components and two or three different components may exist within
the tumour, simultaneously. Metaplastic breast carcinoma normally manifests as
a rapidly growing and palpable large mass (>4-5cm), indicating a high potential
for distant metastases.
It is frequently lymph node negative and in general, it is an aggressive
disease which is more likely to be negative for estrogen receptor (ER),
progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2).
Metaplastic breast carcinoma is usually treated with mastectomy, radiotherapy
and chemotherapy. The prognosis is worse, so early detection and treatment is
the key factor to improve the cure rate. Although there are several reports,
knowledge about molecular pathology of metaplastic carcinoma of the breast is
still limited.
Metaplastic breast carcinomas are of basal-like molecular subtype.
Furthermore, Epithelial to Mesenchymal transition (EMT) is typically defined by
the acquisition of a spindle cell morphology in combination with down
regulation of epithelial genes (for example the loss of membranous E-cadherin)
and up regulation of mesenchymal markers. It is also believed that these
tumours are related with cancer stem cells which can be differentiated into
epithelial and/or mesenchymal component.
Keywords:
Metaplastic carcinoma, Breast cancer, Εpithelial to mesenchymal transition, Molecular profile, HPV
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
40
Number of pages:
68
File:
File access is restricted only to the intranet of UoA.

document.pdf
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