Κατεύθυνση Αναπαραγωγική-Αναγεννητική Ιατρική
Library of the School of Health Sciences

2013-07-24

2013

Καλαντζόπουλος Γεώργιος

Δ. Λουτράδης, Κ. Καλλιανίδης, Κ. Στεφανίδης

Συνδυασμοί γονιδιακών πολυμορφισμών ESR1 και FSHR ως εργαλείο πρόγνωσης πτωχής ωοθηκικής απόκρισης στη θεραπεία υποβοηθούμενης αναπαραγωγής

Greek

SUMMARY
As the area of reproductive medicine is nowadays a constantly evolving field,
showing an exciting progress in both research and pharmaco-economic level, the
application of innovative approaches, as the pharmacogenetic analysis, gains a
growing number of supporters, something that arises from the need for the
continuous improvement of used protocols, so that they are safer and more
effective in fertility treatment.
The genes that have mainly occupied the interest of the majority of research
groups so far, are the FSH receptor (FSHR) and estrogen receptor α and β (ERα,
ERβ).
In this study, we examined the presence and we tried to quantify two
characteristic
receptor polymorphisms of the FSH receptor (Ser680Asn) and estrogen receptor
ESR1 (Pvu II) in greek female patients. Moreover, we attempted to investigate
the
possible association between these polymorphisms (single or combined) and the
outcome of an ART cycle.
This study involved 215 women with normal ovulation who received treatment by
the Department of Human Reproduction (IVF Unit) of the 1st Gynecology and
Obstetrics Clinic of the "Alexandra" Hospital. All women who participated in the
study were infertile for at least one year.
The analysis of the data obtained on the basis of the presence of each
polymorphism separately, showed no statistically significant differences in the
biochemical and clinical profile of patients. Furthermore, although it seemed a
trend for lower pregnancy rates in patients carrying the genotype Asn/Asn, this
was not statistically significant.
The collected data were also studied in combination, based on the presence of
the
polymorphisms of the two separate genes in the same patient. Specifically,
according to the findings of this study, the combination of CC/AA profile
correlates with poor ovulation induction, a small number of collected oocytes
and
low pregnancy rate.
In conclusion, the results indicate that a pharmacogenetic approach that
considers
only one genetic marker is not in line with the complexity of a processes as the
ovarian stimulation, implantation and pregnancy, showing that multifactorial
phenomena need a multivariate pharmacogenetic approach.

IVF, poor ovarian response, genetic polymprphisms, ESR1 , FSHR

Yes

3-4

Yes

75

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https://pergamos.lib.uoa.gr/uoa/dl/object/1313999