Κατεύθυνση Καρκίνος Πνεύμονα: Σύγχρονη Κλινικοεργαστηριακή Προσέγγιση και Έρευνα
Library of the School of Health Sciences

2012-08-08

2012

Βάσσος Δημήτριος

Αναπληρωτής Καθηγητής Συρίγος Ν. Κωνσταντίνος

Aξιολόγιση του βαθμού έκπτωσης της αναπνευστικής λειτουργίας σε ασθενείς με καρκίνο πνεύμονα

Greek

INTRODUCTION
Several studies suggest that lung function impairment can be a predisposing
factor for lung cancer. Increased lung cancer rates have been reported among
individuals with non-malignant lung conditions such as COPD, emphysema and
asthma.
AIM
Retrospective recording of lung function in lung cancer patients, recording of
smoking habits, of any medication followed for lung diseases and correlation of
these factors with disease stage and histological subtype of lung cancer. Also
aims in perspective recording of morbidity and mortality, and their correlation
with the degree of lung function impairment.
METHODS
106 patients were studied retrospectively. They all had submitted lung function
tests at the moment of diagnosis and before they receive any treatment.
Epidemiological and clinical data also recorded, as any medication regarding
respiratory diseases. Smoking habits calculated in pack/years. Patients divided
in groups according GOLD stages of COPD, but 6 patents excluded because of
pleural effusion or atelectasis.
RESULTS
89% were men and 11% were women. Smoking habits, in pack/years had a mean value
69.7 pack/years for men and 50.2 pack/years for women. According to GOLD,39% of
patients had normal lung function. Regarding the frequencies of lung cancer
subtypes, squamous cell was the most frequent 46%, with adenocarcinoma second
for 33%. Statistical analysis didn’t reveal any importance regarding the
correlation of pack/years and histological subtype of lung cancer. Also no
correlation came up according to lung function impairment and smoking habits.
Furthermore there was no statistical difference among histological subtype of
lung cancer in patients with and without lung function impairment (P-VALUE:
0,498) and among those with COPD, histological subtype of lung cancer didn’t
show any correlation with the several stages of COPD nether for medication
received.
On the other hand morbidity was clearly associated with lung functions
impairment. COPD patients had increased rates of hospitalization (P=0,028),
severity of COPD also increased morbidity (P=0.005), Likewise receiving
medication for COPD (P=0.027). Finally mortality is strongly associated with
hospitalization (P<0.001), with duration of hospitalization (P<0.001), and
metastasis at diagnosis (P=0.002).
CONCLUSIONS
Coexistence of lung function impairment has a strong negative effect in
morbidity and mortality of patients with lung cancer. Even if, several studies
suggest that COPD can be a predisposing factor for lung cancer, this didn’t
confirm in this study.

C.O.P.D., Lung cancer, Spirometry, Hystological subtype, Mortality

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https://pergamos.lib.uoa.gr/uoa/dl/object/1314663