Ariel, a long non coding RNA and its role in astrogliogenesis

Postgraduate Thesis uoadl:1314675 266 Read counter

Unit:
Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή Ιατρική
Library of the School of Health Sciences
Deposit date:
2015-09-25
Year:
2015
Author:
Τσιορτού Καλλιόπη - Άννα
Supervisors info:
Παναγιώτης Πολίτης
Original Title:
Ariel, ένα long non coding RNA και ο ρόλος του στην αστρογλοιογένεση
Languages:
Greek
Translated title:
Ariel, a long non coding RNA and its role in astrogliogenesis
Summary:
Although thousands of long non-coding RNAs (lncRNAs) are expressed in the
mammalian nervous system, their roles in brain development are elusive. Here,
we identified lncRNA Ariel as a key regulator of
binary fate decisions in neural stem cells (NSCs) during brain development.
Ariel (831 bp) is transcribed from the Prox1 genomic locus in an anti-parallel
manner in mouse embryonic brain. We have previously
shown that Prox1, a homeobox transcription factor, controls neuronal
differentiation of NSCs during nervous system development (Kaltezioti et al,
PLoS Biology, 2010; Elkouris et al, Stem Cells, 2011; Foskolou et al, Oncogene,
2013; Kaltezioti et al, J Neuroscience, 2014). Collectively, our observations,
presented here, suggest that Ariel - Prox1 genomic locus act as a key
regulator of the switch between neurogenesis and astrogliogenesis in
NSCs.
Keywords:
Neurogenesis, Astrogliogenesis, Neural stem cells, lncRNA Ariel, Brain development
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
78
Number of pages:
76
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