Summary:
The heterozygous b-MA, includes a wide range of phenotypes, and the severity of
clinical form, related directly to the degree of imbalance of a / b chains, and
the excess, a globin.Patients with intermediate b-MA usually they aren't blood
transfusions dipendents, begin treatment, based on clinical and laboratory
image. Decrease of BMD and abnormalities in bone metabolism, charaktirizoyn,
patients with intermediate b-MA. Have been identified, several genetic and
acquired factors involved in the pathogenesis of osteoporosis, which is low
bone turnover, thus, less response to treatment with bisphosphonates.
Keywords:
Heterozygous anemia, Intermediate anemia, Minor anemia, Anemia, Osteoporosis