Unit:
Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή ΙατρικήLibrary of the School of Health Sciences
Supervisors info:
Αν. Καθ. Ι. Κιάρης
Original Title:
Mελέτη του ογκογόνου δυναμικού καρκινικών κυττάρων μαστού πριν και μετά την ανάπτυξή τους σε πειραματικά μοντέλα
Summary:
Cancer is a multifactorial and multistage disease (Moolgavkar & Luebeck, 2003),
which overcomes all obstacles of regulatory mechanisms of the body. Moreover,
it is well-established the fact that with the passage of years, accumulate
mutations in the genome increase the likelihood of developing malignancy. This
thesis dealt with breast cancer due to the fact that it is a frequent cause of
death among women in the modern world. More specifically, the study of
oncogenic potential migrating cells before and after growth in animals
demonstrates that the population of each cell subset derived from different
animal gathers different characteristics because the accumulated different
mutations leading to alternative response to drugs. This refers to malignancies
which often have cytogenetically different clones, derived originally from a
mutant cell via secondary or tertiary genetic changes. This heterogeneity
contributes to differences in clinical behavior and response to therapy of
tumors with similar diagnostic type. Study of the migration potential of cells
derived from different tumors, via in vitro techniques, demonstrated that
despite the effect of the phenomenon of choice, the absence of signaling
pathways that enhance the migration potential in vivo, and the profile of the
cells (epithelial / mesenchymal) are interfering their migration.
Keywords:
Breast cancer, Tumourigenic potential, Animal models, Metastasis, Cancer cells
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