Unit:
Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή ΙατρικήLibrary of the School of Health Sciences
Author:
Γαμπιεράκης Ιωάννης-Αλέξανδρος
Supervisors info:
Καραλή Αικατερίνη, Ερευνήτρια Β' ΙΙΒΕΑΑ, Δάλλα Χριστίνα, Επίκουρη Καθηγήτρια, Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή ΕΚΠΑ, Πολίτης Παναγίωτης, Ερευνητής Δ', ΙΙΒΕΑΑ
Original Title:
O ρόλος της ορμόνης του στρες CRH στην διαδικασία της ενήλικης νευρογένεσης στον Ιππόκαμπο ποντικού
Summary:
Prolonged activation of the stress response has been shown to inhibit adult
neurogenesis in the hippocampus, contributing to the development of brain
diseases. Although existing evidence points to the role for glucocorticoid in
mediating these effects, contradictory data have been reported, and the
mediating mechanisms remain elusive. Studies from our laboratory showed that
Corticotrophin-releasing hormone (CRH), the major mediator of adaptive response
to stressors, could reverse the toxic effects of glucocorticoid on embryonic
neural stem/progenitor cells (NS/PCs). Similarly, we hypothesized that CRH may
exert direct effects on neural precursors of the adult brain.
In the present study, we show that adult hippocampal NS/PCs express both CRH
and CRH receptors, while CRH positively regulates the proliferative activity of
adult neural stem cells and induces neural differentiation ex vivo.
Furthermore, genetic CRH deficiency in mice is associated with significantly
reduced adult hippocampal neurogenesis and hippocampal-depedent cognitive
deficits. CRH hormone is necessary for the induction of adult neurogenesis by
environmental factors (enriched environment) in vivo and is glucocorticoid
independent.
These findings suggest a novel role for CRH in adult neurogenesis. Our results
raise the intriguing possibility for pharmacological applications of CRH in
diseases associated with altered neuronal homeostasis, including depression and
neurodegeneration.
Keywords:
Adult neurogenesis, Glucocorticoids, Enriched enviroment , Corticotropin releasing hormone CRH, Stress axis
Number of references:
122
File:
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