Unit:
Διατμηματικό / Διϊδρυτικό ΠΜΣ Μοριακή ΙατρικήLibrary of the School of Health Sciences
Supervisors info:
Γεώργιος Βασιλόπουλος
Original Title:
O ρόλος του μικροπεριβάλλοντος του μυελού των οστών στη φυσιολογική και παθολογική αιμοποίηση
Summary:
Hepatopoietic stem cells (HSCs) are rare cells that reside in the bone marrow
(BM) and have the ability to perform asymmetric cell divisions for either
self-renewal or differentiation into mature blood cells. Asymmetric cell
division, however, is not autonomous (cell-autonomous) but requires the
assistance of growth factors, proteins of extracellular matrix and cells that
dictate the fate of HSC. This complex network is called hematopoietic stem cell
niche (HSC niche) in the bone marrow. The loss of normal regulation of HSC is
inherent in many hematological malignancies. Myelodysplastic syndromes (MDS)
consist a disease model in which the divergent control divisions and
differentiation of hematopoietic cells has a central role. It is worth noting
that two genes which are active in the hematopoietic nICHE are associated with
the pathogenesis of MDS, that of Wnt and THPO (Thrombopoietin). For this
reason, in the present work we investigated the role of the HSC niche in human
normal and pathological hematopoiesis. Initially, hematopoiesis was studied in
Myelodysplastic Syndromes isolating mesenchymal stem cells from patients with
myelodysplastic syndromes. Then studied the Wnt signaling pathway by silencing
the beta-catenin in co-culture experiments between HSC-MSC and finally
investigated the role of thrombopoietin.
Keywords:
Hsc niche, Bone marrow, WNT pathway, Thrombopoietin, Myelodysplastic syndromes
Number of references:
116
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